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KMID : 0858520080120020115
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Journal of the Korean Society of Magnetic Resonance in Medicine
2008 Volume.12 No. 2 p.115 ~ p.122
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Evaluation of Fibrosis in Liver Cirrhosis by Superparamagnetic Iron Oxide (SPIO)-Enhanced MR Imaging: Does the Radiological Non-Invasive Fibrosis Index Correlate with the Laboratory Non-Invasive Fibrosis Index?
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Kim Shin-Kee
Lee Chang-Hee
Kim Kyeong-Ah
Choi Jae-Woong
Lee Jong-Mee
Park Chul-Min
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Abstract
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Purpose: To evaluate the correlation between the radiological non-invasive hepatic fibrosis index (RNHFI), as determined by SPIO-enhanced MRI, and the laboratory non-invasive hepatic fibrosis index.
Materials and Methods: Patients (99 total: 61 men and 38 women; mean age: 58 years) who underwent SPIO-enhanced MRI (1.5T) during 5 years included. These patients were subdivided into a liver cirrhosis group (LCG) and a non-liver cirrhosis group (non-LCG). Using PACS view, we measured the RNHFI (mean standard deviation of hepatic signal intensity (SD), noise-corrected coefficient of variation (CV)) of three ROIs in the liver parenchyma by SPIO-enhanced MRI. The laboratory non-invasive hepatic fibrosis index (AST-platelet ratio index (APRI)) of all patients was calculated from the laboratory data. We compared the RNHFI and APRI of LCG with those of non-LC group using Student’s t-test. A bivariate correlation was performed to investigate the relationship between the RNHFI and APRI in the LCG.
Results: For the LCG, mean values of SD and CV by SPIO-enhanced MRI were and , respectively. For the non-LCG, mean values of SD and CV were and , respectively. The mean APRI of the LCG and the non- LCG were and , respectively. The RNHFI and APRI were significantly different between both groups (p<0.05). For the LCG, the bivariate correlation between SD and APRI revealed a statistically significant positive correlation (r=0.5, p<0.001). In both groups, there was no statistically significant correlation between CV and APRI.
Conclusion: A measurement of SD can be a simple and useful method for the evaluation of hepatic fibrosis.
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KEYWORD
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Liver, Fibrosis, Cirrhosis, MRI, SPIO, superparamagnetic iron oxide
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